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P2 agonists open calcium-activated, SK potassium channels. (a) Currents in one cell in response to ATP, ADP and UTP (each at 30 μM). The outward currents were completely blocked by the phospholipase C inhibitor U73122 (1 μM). (b) A similar experiment in another cell in which apamin (100 nM) blocked the outward currents. Note that the inward current evoked by ATP was not changed by U73122 or apamin.
