Table 1.
Comparison of the effects of superfusion of 10 μM CCh on action potential properties of single myocytes from left (LA; n=11) and right (RA; n=12) atria. Action potentials were evoked at room temperature at a frequency of 1 Hz. The values before and during superfusion of CCh were compared using two-tailed paired Student's t-tests; difference values were compared using two-tailed unpaired Student's t-tests
| Control | 10μM CCh | Difference | |
|---|---|---|---|
| APD50, LA (ms) | 8.1±1.6 | 3.5±0.3* | 4.8±1.4 |
| APD50, RA (ms) | 11.3±2.6 | 2.6±0.2* | 9.2±2.7 |
| APD90, LA (ms) | 33.2±5.3 | 10.3±1.7** | 23.8±4.0*** |
| APD90, RA (ms) | 57.6±7.3 | 5.6±0.8** | 52.6±7.7 |
| RMP, LA (mV) | −70.7±1.9 | −75.9±1.0** | 5.2±1.0 |
| RMP, RA (mV) | −68.3±1.4 | −72.8±1.0** | 4.8±0.7 |
| AP threshold, LA (nA) n=9 | 0.41±0.016 | 1.0±0.1** | 0.6±0.1 |
| AP threshold, RA (nA) n=10 | 0.39±0.015 | 1.2±0.2** | 0.8±0.2 |
*
P<0.05 versus control.
**
P<0.005 versus control.
***
P<0.05 versus RA.