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Infarct reducing effect of UP. Saline (CON group) or 0.5, 1, 3, 5, 10 and 15 mg kg−1 U50,488 H were given intravenously 24 h before the removal of the heart from the rat. The isolated heart was perfused and then subjected to I/R. n=8 in the CON group and n=6–8 in treatment groups. Values are expressed as mean±s.e.m. **P<0.01 vs CON.
