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. 2003 Sep 22;140(4):595–610. doi: 10.1038/sj.bjp.0705494

Table 2.

Genes significantly upregulated (>1.5-fold, P<0.1) by the combination of HGF and VEGF at 4 h

Sequence derived from Gene symbol Gene description Ratio of HGF+VEGF basal P-value Ratio of VEGF basal P-value Ratio of HGF basal P-value
AK023795.1 ADAMTS1 A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 4.6 <0.01 4.8 <0.01 0.9 0.69
AB003476.1 AKAP12 A kinase (PRKA) anchor protein (gravin) 12 1.6 <0.01 1.2 0.31 1.6 <0.01
M90360.1 AKAP13 A kinase (PRKA) anchor protein 13 1.6 0.04 2.0 <0.01 1.3 0.35
NM_001147.1 ANGPT2 Angiopoietin 2 3.2 <0.01 5.1 <0.01 2.8 <0.01
AF187858.1 ANGPT2 Angiopoietin 2 3.2 <0.01 4.6 <0.01 2.7 <0.01
NM_015985.1 ANGPT4 Angiopoietin 4 3.0 0.08 0.9 0.85 0.7 0.52
NM_016109.1 ANGPTL4 Angiopoietin-like 4 7.6 <0.01 4.6 <0.01 1.7 0.41
NM_012099.1 ASE-1 CD3-epsilon-associated protein; antisense to ERCC-1 1.8 0.02 1.3 0.35 1.7 0.06
NM_001673.1 ASNS Asparagine synthetase 1.5 0.02 1.3 0.25 1.5 0.07
AF095192.1 BAG2 BCL2-associated athanogene 2 1.7 <0.01 1.1 0.8 1.4 0.23
NM_004049.1 BCL2A1 BCL2-related protein A1 6.3 <0.01 2.0 0.23 2.8 0.09
AA583044 BMP2 Bone morphogenetic protein 2 2.0 <0.01 2.1 <0.01 1.7 <0.01
NM_001200.1 BMP2 Bone morphogenetic protein 2 1.9 <0.01 1.7 <0.01 1.4 <0.01
NM_001717.1 BNC Basonuclin 1.9 0.09 1.6 0.32 1.6 0.37
NM_025195.1 C8FW Phosphoprotein regulated by mitogenic pathways 2.1 <0.01 1.5 0.08 1.5 <0.01
NM_005795.1 CALCRL Calcitonin receptor-like 1.5 <0.01 1.2 0.17 1.0 0.89
U17473.1 CALCRL Calcitonin receptor-like 1.5 0.01 1.2 0.32 1.1 0.71
NM_016557.1 CCRL1 Chemokine (C–C motif) receptor-like 1 7.2 <0.01 5.8 <0.01 1.8 0.01
AV700298 CD44 CD44 antigen (homing function and Indian blood group system) 2.0 0.06 2.3 0.06 1.9 0.09
NM_003672.1 CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) 1.9 0.01 2.2 0.01 1.8 0.1
AF115544.1 CDKN2A Cyclin-dependent kinase inhibitor 2A(melanoma, p16, inhibits CDK4) 4.3 0.07 3.5 0.16 1.4 0.81
BC000059.1 CELSR1 Cadherin, EGF LAG seven-pass G-typereceptor 1 (flamingo homolog, Drosophila) 2.5 0.05 2.5 0.14 1.7 0.52
NM_021797.1 CHIA Eosinophil chemotactic cytokine 3.0 0.01 1.0 0.93 2.2 0.38
NM_000748.1 CHRNB2 Cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 6.8 0.03 2.1 0.7 3.0 0.6
NM_013246.1 CLC Cardiotrophin-like cytokine; neurotrophin-1/B-cell-stimulating factor-3 2.6 0.1 1.5 0.58 1.9 0.29
NM_001842.1 CNTFR Ciliary neurotrophic factor receptor 2.8 0.02 2.3 0.08 1.9 0.63
NM_004750.1 CRLF1 Cytokine receptor-like factor 1 5.6 0.03 0.7 0.71 3.1 0.44
D83702.1 CRY1 Cryptochrome 1 (photolyase-like) 1.9 <0.01 1.9 <0.01 1.1 0.42
BC005921.1 CSH1 Chorionic somatomammotropin hormone 1 (placental lactogen) 4.0 0.01 2.0 0.5 3.2 0.13
U83410.1 CUL2 Cullin 2 2.0 0.02 1.7 0.26 2.0 0.16
L01639.1 CXCR4 Chemokine (C–X–C motif) receptor 4 3.0 <0.01 2.8 <0.01 4.2 <0.01
AJ224869 CXCR4 Chemokine (C–X–C motif) receptor 4 2.4 <0.01 2.5 <0.01 3.0 <0.01
AF348491.1 CXCR4 Chemokine (C–X–C motif) receptor 4 1.9 <0.01 1.7 0.04 2.2 0.02
BC003637.1 DDIT3 DNA-damage-inducible transcript 3 1.9 <0.01 3.3 <0.01 1.6 0.1
AL050069.1 DOK5 Docking protein 5 3.1 <0.0 1.5 0.16 1.0 0.81
NM_000796.1 DRD3 Dopamine receptor D3 2.6 0.02 1.5 0.38 2.5 0.13
M60278 DTR Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) 2.6 <0.01 3.8 <0.01 0.7 <0.01
NM_001945.1 DTR Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) 2.2 <0.01 3.1 <0.01 0.7 0.04
BC002671.1 DUSP4 Dual specificity phosphatase 4 9.3 <0.01 8.5 <0.01 3.8 0.11
NM_001394.2 DUSP4 Dual specificity phosphatase 4 5.8 <0.01 6.5 <0.01 2.8 0.03
BC005047.1 DUSP6 Dual specificity phosphatase 6 7.2 <0.01 6.3 <0.01 3.2 0.03
BC003143.1 DUSP6 Dual specificity phosphatase 6 3.1 <0.01 2.5 <0.01 1.7 <0.01
BC003143.1 DUSP6 Dual specificity phosphatase 6 2.9 <0.01 2.7 <0.01 1.7 <0.01
NM_001964.1 EGR1 Early growth response 1 4.7 <0.01 5.8 <0.01 4.4 <0.01
NM_012153.1 EHF ets homologous factor 2.3 0.05 1.1 0.88 1.4 0.64
BF445047 EMP1 Epithelial membrane protein 1 3.2 <0.01 1.9 <0.01 1.9 <0.01
NM_001423.1 EMP1 Epithelial membrane protein 1 2.1 <0.01 1.5 <0.01 1.6 <0.01
NM_001423.1 EMP1 Epithelial membrane protein 1 1.7 <0.01 1.5 <0.01 1.4 <0.01
NM_004438.1 EPHA4 EphA4 3.1 0.06 1.8 0.2 2.2 0.18
NM_001993.2 F3 Coagulation factor III (thromboplastin, tissue factor) 7.8 <0.01 19.1 <0.01 0.8 0.84
NM_012306.1 FAIM2 Fas apoptotic inhibitory molecule 2 3.2 0.02 2.5 0.05 3.0 <0.01
NM_003868.1 FGF16 Fibroblast growth factor 16 2.1 0.03 1.6 0.12 1.1 0.57
U01134.1 FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 13.5 <0.01 4.3 <0.01 2.7 0.01
NM_006732.1 FOSB FBJ murine osteosarcoma viral oncogene homolog B 7.4 <0.01 1.2 0.9 1.0 1
BG251266 FOSL1 FOS-like antigen 1 1.9 <0.01 1.4 <0.01 1.3 0.02
NM_005261.1 GEM GTP binding protein overexpressed in skeletal muscle 1.5 0.01 1.3 0.34 1.0 0.99
U35399.1 GPR4 G protein-coupled receptor 4 1.7 0.08 1.4 0.37 1.8 0.04
AL554008 GPR56 G protein-coupled receptor 56 1.9 <0.01 1.1 0.68 1.5 0.03
U66065.1 GRB10 Growth factor receptor-bound protein 10 1.7 <0.01 1.2 0.01 1.6 <0.01
D86962.1 GRB10 Growth factor receptor-bound protein 10 1.7 <0.01 1.3 0.03 1.5 <0.01
NM_004490.1 GRB14 Growth factor receptor-bound protein 14 1.6 <0.01 1.1 0.47 1.7 <0.01
NM_021643.1 GS3955 GS3955 protein 1.9 0.09 1.8 0.08 0.8 0.58
AI761561 HK2 Hexokinase 2 3.5 <0.01 1.5 0.06 2.6 <0.01
NM_000872.2 HTR7 5-Hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 2.6 0.1 2.1 0.14 1.7 0.49
AA284705 ICAM1 Intercellular adhesion molecule 1 (CD54), Human rhinovirus receptor 1.8 0.07 2.0 0.03 1.5 0.31
NM_000201.1 ICAM1 Intercellular adhesion molecule 1 (CD54), Human rhinovirus receptor 1.8 <0.01 2.6 <0.01 1.1 0.22
AI608725 ICAM1 Intercellular adhesion molecule 1 (CD54), Human rhinovirus receptor 1.7 <0.01 1.8 <0.01 1.0 0.86
M31159.1 IGFBP3 Insulin-like growth factor binding protein 3 5.5 <0.01 2.5 <0.01 0.8 0.65
NM_000641.1 IL11 Interleukin 11 3.4 <0.01 2.2 0.04 1.7 0.22
BF112057 IL-17RC Interleukin 17 receptor C 4.5 0.06 2.3 0.44 2.1 0.5
NM_000600.1 IL6 Interleukin 6 (interferon, beta 2) 1.7 <0.01 3.1 <0.01 1.1 0.59
AF043337.1 IL8 Interleukin 8 2.3 <0.01 3.2 <0.01 0.9 0.68
NM_000584.1 IL8 Interleukin 8 1.9 <0.01 2.1 0.02 1.0 0.88
NM_002192.1 INHBA Inhibin, beta A (activin A, activin AB alpha polypeptide) 1.6 0.04 2.2 0.04 1.0 0.94
NM_002201.2 ISG20 Interferon-stimulated gene 20 k Da 6.8 0.03 3.3 0.35 1.9 0.65
U88964 ISG20 Interferon-stimulated gene 20 k Da 1.9 <0.01 1.2 0.47 1.4 0.18
NM_002203.2 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.9 <0.01 1.5 0.14 1.7 <0.01
AV733308 ITGA6 integrin, alpha 6 1.6 <0.01 1.3 0.11 1.1 0.41
AA215854 ITGB1 Integrin, beta 1 (Fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.6 0.04 3.3 0.04 2.2 0.11
NM_002214.1 ITGB8 Integrin, beta 8 4.1 <0.01 2.6 0.04 2.8 <0.01
BC002630.1 ITGB8 Integrin, beta 8 1.7 0.08 0.9 0.82 1.1 0.86
L38019.1 ITPR1 Inositol 1,4,5-triphosphate receptor, type 1 4.5 0.04 4.9 <0.01 2.4 0.35
NM_002224.1 ITPR3 Inositol 1,4,5-triphosphate receptor, type 3 1.7 0.03 0.9 0.64 1.1 0.57
AL137000 KIAA0970 KIAA0970 protein 1.7 0.05 1.9 <0.01 1.1 0.81
AF119835.1 KITLG KIT ligand 4.3 <0.01 2.2 0.1 1.4 0.53
NM_000899.1 KITLG KIT ligand 2.8 <0.01 1.8 0.01 1.3 0.15
NM_012302.1 LPHH1 Latrophilin 1 2.5 <0.01 2.1 <0.01 1.7 <0.01
NM_017522.1 LRP8 Low-density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1.9 0.02 1.0 0.97 1.4 0.42
AA780381 MAP2K3 Mitogen-activated protein kinase kinase 3 5.9 <0.01 3.5 <0.01 3.2 <0.01
AA780381 MAP2K3 Mitogen-activated protein kinase kinase 3 2.6 <0.01 1.6 <0.01 1.5 <0.01
NM_002756.1 MAP2K3 Mitogen-activated protein kinase kinase 3 2.5 <0.01 1.5 0.02 1.5 <0.01
NM_005204.1 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 2.4 0.03 3.8 <0.01 0.9 0.73
NM_004759.1 MAPKAPK2 Mitogen-activated protein kinase activated protein kinase 2 1.5 <0.01 1.4 <0.01 1.0 0.7
NM_000381.1 MID1 Midline 1 (Opitz/BBB syndrome) 1.5 <0.01 1.7 <0.01 1.2 0.3
AL545921 MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 1.5 0.02 1.5 0.02 1.1 0.44
NM_002467.1 MYC V-myc myelocytomatosis viral oncogene homolog (avian) 1.5 <0.01 1.0 0.67 1.2 0.07
BF337329 NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 10.0 <0.01 7.4 <0.01 5.1 0.01
U08015.1 NFATC1 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.7 <0.01 1.1 0.19 0.9 0.58
AW027545 NFATC1 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.7 0.07 1.2 0.57 0.9 0.73
M55643.1 NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) 1.5 0.01 1.3 0.23 1.1 0.26
NM_006170.1 NOL1 Nucleolar protein1, 120 k Da 1.6 <0.01 1.1 0.59 1.3 <0.01
D21262.1 NOLC1 Nucleolar and coiled-body phosphoprotein 1 2.3 <0.01 1.4 0.01 1.9 <0.01
NM_000271.1 NPC1 Niemann–Pick disease, type C1 1.6 <0.01 1.0 0.76 1.3 0.05
D49728.1 NR4A1 Nuclear receptor subfamily 4, group A, member 1 7.9 <0.01 8.1 <0.01 1.6 0.79
NM_002135.1 NR4A1 Nuclear receptor subfamily 4, group A, member 1 6.6 <0.01 8.5 0.03 1.0 0.98
S77154.1 NR4A2 Nuclear receptor subfamily 4, group A, member 2 3.6 <0.01 2.6 0.02 0.8 0.63
NM_006186.1 NR4A2 Nuclear receptor subfamily 4, group A, member 2 2.4 0.01 2.3 0.06 1.0 0.95
U12767.1 NR4A3 Nuclear receptor subfamily 4, group A,member 3 3.1 <0.01 3.5 0.26 1.3 0.84
AF146343.1 NR5A2 Nuclear receptor subfamily 5, group A, member 2 4.3 <0.01 4.2 <0.01 2.6 <0.01
AF228413.1 NR5A2 Nuclear receptor subfamily 5, group A, member 2 3.2 <0.01 2.6 0.09 2.4 0.07
NM_003822.1 NR5A2 Nuclear receptor subfamily 5, group A, member 2 2.4 0.09 2.2 0.11 1.9 0.18
NM_005010.1 NRCAM Neuronal cell adhesion molecule 1.9 <0.01 1.7 <0.01 1.7 <0.01
NM_013960.1 NRG1 Neuregulin 1 1.5 0.08 1.0 0.93 1.2 0.59
NM_012377.1 OR7C2 Olfactory receptor, family 7, subfamily C, member 2 5.4 0.04 1.5 0.58 1.3 0.42
X03795.1 PDGFA Platelet-derived growth factor alpha polypeptide 4.1 0.03 1.4 0.61 1.7 0.44
NM_002607.1 PDGFA Platelet-derived growth factor alpha polypeptide 3.0 <0.01 1.1 0.44 1.8 <0.01
NM_007169.1 PEMT Phosphatidylethanolamine N-methyltransferase 1.7 0.1 1.3 0.67 1.5 0.4
AA576961 PHLDA1 Pleckstrin homology-like domain, family A, member 1 1.7 <0.01 1.3 0.17 1.1 0.56
NM_006875.1 PIM2 pim-2 oncogene 1.7 0.02 1.6 <0.01 1.0 0.85
NM_002658.1 PLAU Plasminogen activator, urokinase 1.8 <0.01 1.3 0.05 0.7 <0.01
K03226.1 PLAU Plasminogen activator, urokinase 1.7 <0.01 1.1 0.53 0.6 <0.01
AY029180.1 PLAUR Plasminogen activator, urokinase receptor 7.8 <0.01 3.3 0.03 2.8 0.03
U08839.1 PLAUR Plasminogen activator, urokinase receptor 3.3 <0.01 1.7 <0.01 1.6 <0.01
NM_025179.1 PLXNA2 Plexin A2 1.8 0.01 1.7 <0.01 1.3 0.17
AI688418 PLXNA2 Plexin A2 1.6 <0.01 1.4 <0.01 1.2 <0.01
NM_002674.1 PMCH Pro-melanin-concentrating hormone 17.0 <0.01 5.6 <0.01 2.1 0.47
L03203.1 PMP22 Peripheral myelin protein 22 2.8 <0.01 2.0 <0.01 1.6 <0.01
NM_003967.1 PNR Putative neurotransmitter receptor 3.5 0.1 1.1 0.97 0.4 0.58
BC000535.1 PPAN Peter pan homolog (Drosophila) 2.3 0.08 1.3 0.49 1.3 0.49
AF014403.1 PPAP2A Phosphatidic acid phosphatase type 2A 1.8 <0.01 2.8 <0.01 1.1 0.34
AB000888.1 PPAP2A Phosphatidic acid phosphatase type 2A 1.8 <0.01 2.5 <0.01 1.1 0.62
AB000889.1 PPAP2B Phosphatidic acid phosphatase type 2B 6.3 <0.01 4.8 <0.01 1.7 <0.01
AL576654 PPAP2B Phosphatidic acid phosphatase type 2B 4.4 <0.01 3.5 <0.01 1.5 <0.01
BC005961.1 PTHLH Parathyroid hormone-like hormone 13.2 <0.01 2.8 0.07 6.0 <0.01
NM_002820.1 PTHLH Parathyroid hormone-like hormone 7.8 <0.01 1.7 0.28 2.9 <0.01
J03580.1 PTHLH Parathyroid hormone-like hormone 3.6 0.01 1.0 0.96 1.7 0.32
NM_002849.1 PTPRR Protein tyrosine phosphatase, receptor type, R 2.3 0.05 1.4 0.63 1.7 0.41
BE615277 PVR Poliovirus receptor 1.5 <0.01 1.3 0.29 1.1 0.59
NM_000319.1 PXR1 Peroxisome receptor 1 1.5 0.05 1.2 0.34 1.2 0.2
AI817041 RDC1 G protein-coupled receptor 1.7 <0.01 1.5 0.12 0.9 0.45
NM_002923.1 RGS2 Regulator of G-protein signalling 2, 24 k Da 4.5 <0.01 2.1 <0.01 1.5 <0.01
BF062629 RIS1 Ras-induced senescence 1 7.6 <0.01 1.8 0.26 2.8 0.02
NM_002575.1 SERPINB2 Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 3.5 <0.01 1.5 0.13 2.5 <0.01
NM_003012.2 SFRP1 Secreted frizzled-related protein 1 2.0 0.02 1.2 0.51 1.3 0.37
AF017987.1 SFRP1 Secreted frizzled-related protein 1 1.7 0.05 1.1 0.8 1.0 0.84
NM_005627.1 SGK Serum/glucocorticoid regulated kinase 2.0 <0.01 2.1 <0.01 1.2 0.24
AF153330.1 SLC19A2 Solute carrier family 19 (thiamine transporter), member 2 1.7 0.01 1.3 0.11 1.4 0.09
NM_005415.2 SLC20A1 Solute carrier family 20 (phosphate transporter), member 1 2.8 <0.01 1.4 <0.01 1.9 <0.01
AW452623 SLC7A1 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.1 <0.01 2.1 0.01 1.2 0.51
NM_003045.1 SLC7A1 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.0 0.02 1.9 0.08 0.8 0.37
NM_014720.1 SLK Ste20-related serine/threonine kinase 1.5 0.04 1.3 0.08 1.1 0.36
AB004903.1 SOCS2 Suppressor of cytokine signaling 2 2.3 0.05 1.4 0.55 1.7 0.29
NM_003877.1 SOCS2 Suppressor of cytokine signaling 2 1.8 0.06 1.1 0.74 0.9 0.77
NM_003155.1 STC1 Stanniocalcin 1 30.9 <0.01 7.8 <0.01 1.4 0.44
AI300520 STC1 Stanniocalcin1 12.9 <0.01 3.6 0.03 0.8 0.47
U46768.1 STC1 Stanniocalcin 1 11.0 <0.01 4.3 <0.01 1.1 0.87
NM_005990.1 STK10 Serine/threonine kinase 10 1.9 0.01 1.9 0.08 1.1 0.68
BE550452 SYN47 Homer, neuronal immediate early gene, 1B 2.6 0.09 2.5 0.12 2.5 0.07
NM_015727.1 TACR1 Tachykinin receptor 1 3.4 0.1 2.7 0.21 3.4 0.05
J04152 TACSTD2 Tumor-associated calcium signal transducer 2 1.9 <0.01 1.1 0.5 1.1 0.55
D38081 TBXA2R Thromboxane A2 receptor 1.5 0.04 0.9 0.55 1.3 0.1
NM_030751.1 TCF8 Transcription factor 8 (represses interleukin 2 expression) 1.9 0.02 1.5 0.15 1.6 0.14
NM_000361.1 THBD Thrombomodulin 4.9 <0.01 3.4 <0.01 1.4 0.04
NM_000361.1 THBD Thrombomodulin 4.9 <0.01 3.1 0.06 1.3 0.7
NM_003254.1 TIMP1 Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) 1.7 <0.01 1.2 0.1 1.4 <0.01
NM_003823.1 TNFRSF6B Tumor necrosis factor receptor superfamily, member 6b, decoy 1.6 <0.01 0.9 0.77 1.3 0.21
NM_005118.1 TNFSF15 Tumor necrosis factor (ligand) superfamily, member 15 2.2 <0.01 1.6 0.16 1.3 0.5
NM_016179.1 TRPC4 Transient receptor potential cation channel, subfamily C, member 4 2.6 0.09 2.5 0.09 3.2 <0.01
AF001294.1 TSSC3 Tumor suppressing subtransferable candidate 3 1.6 <0.01 1.0 0.84 1.5 0.04
U58111.1 VEGFC Vascular endothelial growth factor C 1.7 <0.01 1.4 0.01 1.3 0.11
AI983115 WSX1 Class I cytokine receptor 3.8 0.02 1.9 0.43 3.1 0.06
NM_004843.1 WSX1 Class I cytokine receptor 2.2 0.09 1.0 0.94 1.4 0.44
NM_005283.1 XCR1 Chemokine (C motif) receptor 1 3.2 0.03 2.8 0.27 3.2 0.15
NM_016164.2 XLKD1 Extracellular link domain containing 1 2.2 0.06 2.8 0.07 0.6 0.58
U87460.1   Putative endothelin receptor type B-like protein [Homo sapiens], mRNA sequence 5.1 <0.01 4.2 <0.01 2.4 0.19
NM_004367.1   Chemokine (C–C motif) receptor 6; chemokine (C–C) receptor 6; G proteincoupled receptor 29; seven-transmembrane receptor, lymphocyte, 22; chemokine receptor-like 3 [Homo sapiens], mRNA sequence 2.3 0.09 1.7 0.3 1.4 0.6
AA058828   Soluble vascular endothelial cell growth factor receptor (A49636) 1.7 0.03 2.6 0.01 1.5 0.02