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Comparison of the electrophysiological parameters of HERG channel block by dronedarone and amiodarone
| Amiodarone (Kiehn et al., 1999) | Dronedarone (this study) | |
|---|---|---|
| IC50 | 9.8 μM | 9.2 μM |
| Maximum inhibition | 62.8% | 85.2% |
| Blocked states | Closed, open, inactivated | Closed, open, inactivated |
| Voltage dependence | + | + |
| Frequency dependence | + | − |
