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. 2003 Sep 22;140(5):907–912. doi: 10.1038/sj.bjp.0705503

Figure 2.

Figure 2

Effects of rivastigmine on IK(A) and IK(DR) recorded following a depolarizing test pulse to +40 from −50 mV. (a) Superimposed current traces obtained at +40 mV in control conditions, 5 min after the application of 100 μM rivastigmine and after washout of the drug. IK(A) was obtained by digital subtraction. The effects of rivastigmine were readily reversible on washout of the drug. The decay time constant of IK(A) was fitted by a monoexponential function. In the presence of 100 μM rivastigmine, the rate of IK(A) inactivation was 24.3 ms compared with 7.1 ms in control. (b) Concentration–response curves for the blocking action of rivastigmine on IK(A) and IK(DR). Data were fitted with the equation: I/Icontrol=100−[max/1+(IC50/C)n]. For IK(A), IC50=3.8 μM, n (the Hill coefficient)=0.88 and max=65.9%. For IK(DR), IC50=1.7 μM, n=0.67 and max=67.3%. The numbers above each data point indicate the numbers of patches used to construct the points.