Table 1.
Time spent in drug-associated compartment during the preconditioning and the testing phase
| Preconditioning (s) | Testing (s) | |
|---|---|---|
| (a) MDMA-induced place preferencea | ||
| Saline | 369±16 | 367±32 |
| MDMA 1 mg kg−1 | 365±10 | 386±21 |
| MDMA 3 mg kg−1 | 360±15 | 388±20 |
| MDMA 9 mg kg−1 | 335±5 | 416±17## |
| (b) Effect of SL327 pretreatment on MDMA-induced place preferenceb | ||
| DMSO/saline | 331±21 | 347±25 |
| SL327/saline | 330±14 | 369±28 |
| DMSO/MDMA | 331±13 | 418±20# |
| SL327/MDMA | 327±12 | 331±14** |
a
Values are mean±s.e.m. from nine or 10 independent mice per group.
##
P<0.01 as compared to saline-treated group (Fisher–PLSD).
b
Values are mean±s.e.m. from seven or eight independent mice per group.
#
P<0.05 as compared to control group;
**
P<0.01 as compared to MDMA-treated group (Fisher–PLSD). Statistical analysis was performed on the scores data, calculated as the difference between testing and preconditioning times spent in drug-associated compartment.