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WAY-855 does not activate ionotropic glutamate receptors. Rapid application (200 ms) of 1 mM WAY-855 did not activate a mixed glutamate receptor current in cultured hippocampal neurones (grey trace). In contrast, 1 mM L-glutamate activated a large desensitising inward current (black trace). Representative profiles are presented. Grey bar indicates period of drug application.
