Figure 1.
Effect of the treatment with rolipram on the influx of leukocytes (a) in the BAL fluid or (b) in the lungs of mice infected with K. pneumoniae. Animals were inoculated with 3 × 106 bacteria or vehicle (30 μl, not infected) and evaluated 24 h after infection. Rolipram (Rol, 3–30 mg kg−1) was administered 24 and 2 h prior to inoculation of bacteria. MPO activity in the lungs was used as an index of neutrophil influx in that tissue. Results are shown as the number of leukocytes or leukocyte index and represent the mean±s.e.m. of six animals in each group. *P<0.01 when compared with noninfected mice and # for P<0.01 when compared to vehicle-treated mice.