Table 1.
Percentage of BAL fluid neutrophils containing bacteria in the cytoplasm
| Groups | % neutrophils containing bacteria |
| Vehicle treated | 78.2±6.5 |
| Rolipram treated | |
| 3 mg kg−1 | 63.1±4.8 |
| 10 mg kg−1 | 32.6±8.9* |
| 30 mg kg−1 | 30.0±2.0* |
Animals were inoculated with 3 × 106 bacteria or vehicle (30 μl) and the percentage of neutrophils containing bacteria in the cytoplasm was assessed after 24 h. Rolipram (10 mg kg−1) was administered 24 and 2 h prior to the inoculation of bacteria. Results are shown as the mean±s.e.m. of five to six animals in each group.
*
P<0.01 when compared with vehicle-treated mice.