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. 2003 Oct 6;140(6):1088–1096. doi: 10.1038/sj.bjp.0705534

Figure 4.

Figure 4

Antagonism of the synaptic depressant effect of EM by the selective μ-opioid receptor antagonist β-funaltrexamine. EM-1 (3 μM) applied by superfusion, as indicated by two arrows, depressed EPSCs to about 20% of control, without causing a change of holding current. Second application of EM-1 in the presence of β-FNA (25 μM, solid line) caused no appreciable change of EPSCs. Upper traces are continuous chart recordings. Lower traces are averaged EPSCs taken from upper traces at times marked by letters a–f. Averaged EPSCs before and after EM-1 are superimposed in a and b; a and c are averaged EPSCs before and after wash, a and d are averaged EPSCs before addition and after washout of EM-1; a and e are averaged EPSCs before first and second application of EM-1; e and f are superimposed EPSCs taken before and after application of EM-1 in the presence of β-FNA.