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Suppression of IPSCs by opioids in SG neurons of rat spinal cord. EM-1 (1 μM), DAMGO (5 μM) and [met5] enkephalin (10 μM) reduced IPSCs to 40, 57 and 45% of control in a reversible manner. The membrane potential was held at −60 mV. Recordings were obtained from three different SG neurons. IPSCs exhibited a long synaptic latency, indicating their polysynaptic nature.
