Table 1.
Concentration–response curve data from chlormethiazole application to different human GABAA receptor subtypes
| Subtype | EC50 (μM) | Max potentiation (% of control) | Hill coefficient | n |
|---|---|---|---|---|
| α1β2 | 81.7 (76.1, 87.8) | 526±61 | 1.6 | 4 |
| α1β2γ2 | 43.3 (36.9, 44.3) | 298±24 | 1.1 | 8 |
| α1β1γ2 | 21.7 (19.2, 24.4) | 264±31 | 1.0 | 4 |
| α4β2γ2 | 87.1 (78.6, 96.5) | 646±57 | 1.5 | 4 |
| α6β2γ2 | 162 (121, 218) | 695±188 | 1.1 | 4 |
EC50 is shown as mean and 95% confidence limits. Maximum potentiation of an EC20 control GABA concentration is shown as arithmetic mean±s.e. Hill coefficient is that of the curve fitted through the mean data points for each subtype.