Table 2.
The internal diameter (i.d.) and resting tension of isolated segments of MCA, and the contractile response to either 127 mmol l−1 KCl-PSS (Emax), 40 mmol l−1 KCl-PSS (40 K+), or N-nitro-L-arginine (L-NNA) of sham-operated (Sham), ovariectomized (OVX), and tamoxifen-treated OVX (OVX+TAM) rats
| Groups | n | i.d. (μm) | Resting tension (mg) | Emax (mg) | 40 K+ (%Emax) | L-NNA (%Emax) |
|---|---|---|---|---|---|---|
| Sham | 8 | 167±5 | 129±7 | 500±35 | 53±5 | 8±3 |
| OVX | 8 | 178±9 | 186±15* | 618±51* | 72±4* | 34±12* |
| OVX+TAM | 8 | 180±9 | 142±12† | 525±54† | 76±4* | 23±12 |
Results are expressed as mean±s.e. All PSS contained indomethacin (10 μmol l−1).
*
P<0.05 versus Sham;
†
P<0.05 versus OVX (ANOVA, Scheffé's F test).