Figure 2.

Effect of marrubenol on the cytosolic calcium concentration and contractile tension in a fura-2-loaded aortic ring. (a) Typical traces of Ca²⁺ signal (upper trace) and contraction (lower trace). The artery was stimulated with 100 mM KCl solution. Marrubenol (30 μM) was added into the cuvette at the plateau of the contraction (as indicated). (b) Bar graphs representing the mean values (n=5) of the effect of marrubenol 5 and 30 μM on the Ca²⁺ signal (upper panel) and the contraction (lower panel). Data were expressed as percentages of the responses measured immediately before the addition of marrubenol, and were corrected for the decrease in responses measured in time-matched controls.