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Time course of the effects of CNP (10 nM) on coronary flow and heart rate in isolated working WT (open circles) and PKG ITG (filled circles) hearts. CNP was added at time zero (arrow) and infused for 50 min in both panels. Data are expressed as % of baseline (at 0 min) and represent the mean±s.e.m. from eight experiments per genotype. *P<0.05 vs baseline (at 0 min).
