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Peak effects of isoproterenol (100 nM) on heart rate (HR), left ventricular systolic pressure (LVPmax), maximal rates of contraction (dP/dtmax) and relaxation (dP/dtmin), time to relaxation (Timerelax) and coronary flow (CF) in isolated working WT and PKG ITG (filled columns) hearts. Data are expressed as % change vs baseline and represent the mean±s.e.m. from five experiments per genotype. *P<0.05 vs baseline (at 0 min).
