Table 1.
Baseline parameters of isolated hearts from WT and PKG ITG mice in the work-performing mode
| Baseline parameters | WT | PKG ITG |
|---|---|---|
| Heart weight (mg) | 179±2 | 182±2 |
| Heart/body weight ratio (mg g−1) | 6.3±0.2 | 6.4±0.3 |
| CF (ml min−1 g−1) | 16.8±1.0 | 16.9±0.5 |
| HR (b.p.m.) | 360±8 | 371±6 |
| Mean aortic pressure (mmHg) | 51.3±0.1 | 52.1±0.3 |
| Intraventricular pressure (mmHg) | ||
| Systolic | 87±1.4 | 87±1.5 |
| Diastolic | −0.9±0.8 | −0.3±0.9 |
| Time to peak pressure (ms) | 34.3±0.6 | 35.0±0.4 |
| Time to relaxation (ms) | 46.3±0.5 | 44.5±1.0 |
| +dP/dt (mmHg s−1) | 3067±21 | 3105±17 |
| −dP/dt (mmHg s−1) | 2559±74 | 2669±87 |
Perfusion conditions: preload of 30 ml min−1 g−1 (intra-atrial pressure of 7±2 mmHg), afterload of 50 mmHg aortic pressure. CF: coronary flow; HR: heart rate; +dP/dt, maximal rate of contraction; −dP/dt, maximal rate of relaxation. Values are means±s.e.m. (n=27 per genotype).