Table 1.

Summary of the action of a number of analgesic compounds against mechanical hyperalgesia (a) and tactile allodynia (b) in a rat model of incisional pain

Compound	Doses (mg kg−1)	Route	MED (mg kg−1)	Onset of action	Duration of action	Maximum percent reversal	ED50 (mg kg−1)
(a) Paw pressure
Morphine	1, 3, 10, 20	s.c.	3	By 1 h	Short	100 % (1 h)	1.9
Gabapentin	10, 30, 100	i.p.	30	By 1 h	Medium	64% (1 h)	11.3
Indomethacin	1, 3, 10, 30	p.o.	10	By 1 h	Medium	84 % (1 h)	2.8
Naproxen	3, 10, 30	p.o.	30	By 1 h	Long	31% (3 h)	93
Celecoxib	3, 10, 30	p.o.	10	By 1 h	Medium	45% (1 h)	4.1
Etoricoxib	3, 10, 30	p.o.	10	By 1 h	Long	56% (3 h)	28.8
(b) Electronic von Frey
Morphine	1, 3, 10, 20	s.c.	1	By 1 h	Short	100% (1 h)	0.81
Gabapentin	10, 30, 100	i.p.	30	By 3 h	Short	19% (3 h)	3.4
Indomethacin	1, 3, 10, 30	p.o.	10	By 3 h	Short	46% (5 h)	7.1
Naproxen	3, 10, 30	p.o.	30	By 3 h	Medium	43% (3 h)	20.2
Celecoxib	3, 10, 30	p.o.	10	By 3 h	Medium	47% (3 h)	8.9
Etoricoxib	3, 10, 30	p.o.	10	By 1 h	Long	70% (3 h)	10.1

MED is defined as the minimum dose that elicits a statistically significant reversal as compared to vehicle-treated controls. Onset of action is defined as the earliest detected statistically significant reversal with the MED. Duration of action is defined as short – the MED elicited a statistically significant reversal at only one of the time points postadministration, medium – the MED elicited a statistically significant reversal at two of the time points postadministration, long – the MED elicited a statistically significant reversal at three of the time points postadministration. Maximum percent reversal is reported for the highest dose studied. ED₅₀ is defined as the dose which produces 50% of its maximum effect. s.c. – subcutaneous, i.p. – intraperitoneal, p.o. – oral gavage, MED – minimum effective dose.