Table 1.
Parameters describing the systemic and pulmonary impact of hypoxia (H), treatment of hypoxic rats with tempol (HT), molsidomine (HM), and the combination of molsidomine and tempol (HTM) compared to a normoxic control group (N)
| Body weight (g) | Heart rate (min−1) | Lungs (% of body weight) | Liver (% of body weight) | |
|---|---|---|---|---|
| N | 336±7 | 351±6 | 0.57±0.03 | 4.28±0.15 |
| H | 291±8* | 364±7 | 0.83±0.04* | 4.36±0.15 |
| HT | 226±14* | 365±6 | 0.86±0.07* | 3.97±0.14 |
| HM | 226±15*# | 375±2 | 0.91±0.08* | 3.43±0.25*# |
| HTM | 247±17*# | 382±3 | 0.14±0.08* | 3.97±0.26 |
Values are mean±s.e.m. of 8-13 animals examined. Differences were evaluated by one way analysis of variance (ANOVA) followed by a posteriori Bonferroni test in case of significance: *P<0.05, parameter significantly different compared to N
#
P<0.05, parameter significantly different compared with H.