Table 2.
Contractile responses evoked by 125 mM K+-rich U46619 (100 nM), and endothelin-1 (ET-1, 30 nM) in proximal and distal pulmonary arteries from normoxic (N), vehicle-treated hypoxic (H), and hypoxic rats treated with tempol (HT), molsidomine (HM), and tempol plus molsidomine (HTM)
| N | H | HT | HM | HTM | |
|---|---|---|---|---|---|
| (n=8–9) | (n=8) | (n=5–8) | (n=5–7) | (n=6–8) | |
| Poximal | |||||
| Diameter (μm) | 1296±90 | 958±78* | 1200±51# | 835±41* | 818±61* |
| KPSS (N m−1) | 1.1±0.2 | 1.3±0.1 | 1.3±0.2 | 2.1±0.9 | 0.9±0.2 |
| U46619 (N m−1) | 1.1±0.2 | 1.5±0.1 | 1.2±0.1 | 2.3±0.8* | 1.1±0.1 |
| ET-1 (N m−1) | 0.9±0.2 | 0.7±0.2 | 1.7±0.2 | 2.8±1.1 | 1.8±0.8 |
| Distal | |||||
| Diameter (μm) | 660±85 | 515±70 | 430±53 | 549±45 | 305±77* |
| KPSS (N m−1) | 1.5±0.4 | 1.5±0.5 | 1.3±0.4 | 3.7±1.0* | 1.1±0.4 |
| U46619 (N m−1) | 1.5±0.3 | 1.3±0.4 | 0.3±0.3 | 3.0±0.7* | 1.0±0.4 |
| ET-1 (N m−1) | 1.7±0.3 | 1.7±0.5 | 1.0±0.2 | 2.6±0.7 | 1.3±0.5 |
Values are mean±s.e.m., where n indicates the number of animals. Differences were evaluated by one-way analysis of variance (ANOVA) followed by a posteriori Bonferroni test in case of significance: *P<0.05 versus arteries from normoxic animals
#
P<0.05 versus arteries from hypoxic rats.