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Summary of the effects of ORL1 ligands on spontaneous locomotor activity in mice
| Effect of putative ORL1 antagonists and naloxone | |||||
|---|---|---|---|---|---|
| ORL1 ligands | Effect | NNN | NBZ | UFP-101 | Naloxone |
| NC low doses | Stimulation | Blockade | Blockade | Blockade | 0 |
| NC high doses | Inhibition | Blockade | Blockade | Blockade | 0 |
| Ro 64-6198 | Inhibition | 0 | 0 | Blockade | Potentiation |
0–no significant effect.
