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InsP3 (a; applied in the pipette) and OAG (b, c; applied in the external solution) have no effect on mICAT or its inhibition by U-73122. In the experiment shown in (a), carbachol was applied 5 min after breakthrough with 1 μM InsP3 in the pipette solution. (b, c) OAG was applied in the external solution. In the inset in (b), a magnified segment of the current trace is shown on the same time scale. Holding potential was −40 mV throughout.
