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. 2003 Dec 8;141(1):183–193. doi: 10.1038/sj.bjp.0705602

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Copyright 2004, Nature Publishing Group

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Effects of forskolin, 8Br-cGMP, 2-APB and levcromakalim on the correlation between calcium transients and mechanical activity. In a bladder smooth muscle preparation, which exhibited spontaneous calcium transients (Aa) and corresponding contractions (Ac), forskolin (0.1 μM) reduced the frequency of calcium transients without changing their amplitude (Ab), and reduced the amplitude of the contractions (Ad). In the same preparation, 8Br-cGMP (0.1 mM) reduced the frequency of calcium transients without changing their amplitude (Bb), and suppressed corresponding contractions (Bd). In a different preparation, 2-APB (30 μM) increased the frequency of calcium transients without changing their amplitude (Cb), and reduced the amplitude of corresponding contractions (Cd). In another preparation, levcromakalim (0.1 μM) reduced the frequency of calcium transients without changing their amplitude (Db). It also reduced the frequency of phasic contractions but did not change their amplitude (Dd).