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Affinities of orexin-A, orexin-B, SB-334867, SB-410220, SB-408124 and SB-674042, as measured by [3H]SB-674042 binding or calcium mobilisation
| Orexin-A | Orexin-B | SB-334867 | SB-408124 | SB-410220 | SB-674042 | |
|---|---|---|---|---|---|---|
| Kb, OX1 (nM) | nd | nd | 27.8±2.6 | 21.7±2.3 | 8.7±0.8 | 1.1±0.1 |
| Kb, OX2 (nM) | nd | nd | 1704±266 | 1405±284 | 503±90 | 129±15 |
| Ki, SPA OX1 (nM) | dnb | dnb | 38.7±3.6 | 26.9±4.1 | 4.5±0.2 | nd |
| Ki, whole-cell OX1 (nM) | 318±158 | 1516±596 | 57±8.3 | 99±18 | 18.5±4.5 | nd |
nd – value not determined; dnb – did not bind up to 10 μM.
