Table 2.

Effect of phenylephrine on mesenteric arteriolar diameter in the absence and presence of N^G-nitro-L-arginine (L-NNA) in streptozotocin-diabetic and control rats

	pEC50	Rmax (%)	n
L-NNA (−)
Control	5.17±0.07	53.9±9.0	6
Streptozotocin	5.54±0.06**	52.7±3.8	6
L-NNA (+)
Control	5.59±0.09##	58.6±4.0	6
Streptozotocin	6.07±0.03**##	57.9±3.8	6

Each value represents the mean±s.e.m. for the number (n) of experiments. pEC₅₀: −log EC₅₀. R_max: The maximal response to phenylephrine is shown as a percentage of the inner diameter before the application of the drug. L-NNA (0.1 mM) was applied 15 min before the application of phenylephrine.

^**P<0.01 compared to the corresponding control value.

^##P<0.01 compared to the corresponding value of L-NNA (−).