Table 1.
Effects of Indomethacin, BAYu3405, mepyramine and metiamide on the contraction induced by LTB4 in the GPLP and GPPA
| Group | n | AUC (whole) 0–10 min | AUC (early) 0–1 min |
|---|---|---|---|
| GPLP | |||
| Control | 6 | 325.8±18.0 | 17.33±2.42 |
| BAY | 3 | 104.2±17.6a | 6.84±1.41a |
| Indo | 3 | 102.9±30.4a | 5.02±1.78a |
| Mep+Met | 6 | 286.6±21.6 | 9.23±1.06a |
| BAY+Mep+Met | 3 | 143.5±21.4a,b | −0.71±0.91a,b |
| Indo+Mep+Met | 3 | 95.6±6.8a,b | 0.28±0.12a,b |
| GPLP with U-75302 (1 μM) | 0–10 min | 0–1 min | |
| Control | 4 | 188.6±36.9 | 6.40±0.97 |
| BAY | 4 | 61.6±15.1a | 0.67±0.38a |
| Mep+Met | 4 | 215.9±32.1 | 7.16±1.62 |
| BAY+Mep+Met | 4 | 69.9±24.8a,b | 0.26±0.41a,b |
| GPPA | 0–5 min | 0–1 min | |
| Control | 7 | 57.7±10.9 | 15.83±2.41 |
| BAY | 7 | 27.0±9.4a | 11.11±3.13 |
| Mep+Met | 7 | 19.7±6.1a | 4.68±1.31a |
| BAY+Mep+Met | 7 | 1.2±0.5a | −0.05±0.08a,c |
Each data represent the mean±s.e.m. of n experiments. LTB4 was administered at 100 nM (GPLP) and 1 μM (GPPA). BAY, Indo, Mep and Met means BAYu3405 3 μM, indomethacin 10 μM, mepyramine 1 μM and metiamide 1 μM, respectively.
a
P<0.05 vs control
b
P<0.05 vs Mep+Met (Tukey test)
c
P<0.05 vs BAY or Indo.