Table 2.
Antagonist Ki values (μM) for inhibiting the responses of recombinant NMDA receptors expressed in Xenopus oocytes (means±s.e.m. (n))
| NR1a/NR2A | NR1a/NR2B | NR1a/NR2C | NR1a/NR2D | |
|---|---|---|---|---|
| (R)-α-AA | 6.5±0.6D (5) | 24.7±4.1D,c (7) | 43.9±2.8D (5) | 114±23 (5) |
| (R)-CPP | 0.041±0.003D,c* (6) | 0.27±0.02d* (5) | 0.63±0.05D (5) | 1.99±0.20 (5) |
| PBPDa | 15.79±0.43b,c,d | 5.01±0.25c | 8.98±0.18d | 4.29±0.11 |
| PEAQX | 0.0054±0.0004B,D (5) | 0.067±0.003C,D (5) | 0.0116±0.0009C (5) | 0.037±0.004 (4) |
| PPDA | 0.55±0.15b,C,D (3) | 0.31±0.02c,d (5) | 0.096±0.006 (4) | 0.125±0.035 (5) |
| UBP112 | 13.2±0.89D (5) | 18.0±2.4D (4) | 27.0±3.1D (5) | 59.7±8.5 (6) |
| UBP106 | 7.97±0.77c (4) | 9.36±1.41c* (6) | 4.42±0.40 (6) | 6.45±0.40 (5) |
| UBP101 | 42.9±5.3b*,C,D (4) | 22.1±5.2 (5) | 8.49±0.72 (4) | 12.9±1.1 (4) |
| UBP131 | 9.6±1.1B,C (5) | 18.2±1.3C,D (5) | 3.89±0.09D (5) | 9.26±0.43 (6) |
| UBP102 | 8.78±0.88B (5) | 13.4±0.8C,D (5) | 7.38±0.38 (5) | 8.02±0.31 (5) |
b, c, d, significantly different from NR2B, NR2C and NR2D, respectively; P<0.05.
b*, c*, d*, significantly different from NR2B, NR2C and NR2D, respectively; P<0.01.
B, C, D, significantly different from NR2B, NR2C and NR2D, respectively; P<0.001.
a
n=4–6; PBPD results from Buller et al. (1997).