Figure 1.

Leukocyte (a) rolling and (b) firm adhesion in hepatic postsinusoidal venules 6 h after treatment with a combination of LPS (10 μg) and Gal (18 mg) in wild-type (WT) or LFA-1-deficient mice (−/−). Negative control animals received PBS. Animals were pretreated with a monoclonal Ab against LFA-1 (M17/4.4.11.9, 100 μg per mouse) and a control Ab (9-A2, 100 μg per mouse) or PBS. Data represent means±s.e.m. and n=5–8. ^#P<0.05 vs LPS-treated wild-type mice and ^*P<0.05 vs control Ab.