Table 1.

Systemic leukocyte counts

	MNL	PMNL	Total
Control	2.4±0.4	0.7±0.1	3.1±0.4
PBS+LPS/Gal	3.1±0.4	1.6±0.2	4.8±0.6
LFA-1−/−+LPS/Gal	4.5±1.5	1.7±0.3	6.2±1.6
Control ab+LPS/Gal	3.0±0.4	1.2±0.4	4.2±0.6
Anti-LFA-1 ab+LPS/Gal	4.6±1.0	1.0±0.2	5.6±1.2

Leukocytes were counted in a hematocytometer and defined as mononuclear (MNL) or polymorphonuclear (PMNL). Animals received a combination of LPS (10 μg) and D-galactosamine (Gal, 18 mg) in wild-type or LFA-1-deficient mice (−/−). Negative control animals received PBS (Control). Animals were pretreated with a monoclonal antibody against LFA-1 (M17/4.4.11.9, 100 μg per mouse) and a control antibody (9-A2, 100 μg per mouse) or PBS. Data represent means±s.e.m., and n=5–8.