Table 1.
Single “Cosinor” analysis on circadian variations of (a) UH2/Ura ratios and PBMC DPD levels in healthy subjects; (b) UH2/Ura ratios, liver DPD levels and PBMC DPD levels in rats
| Mesor | Amplitude | r2 | P | Maximum | Minimum | Maximum/minimum | Tmax (h: mm) | Tmin (h: mm) | |
|---|---|---|---|---|---|---|---|---|---|
| (a) | |||||||||
| Human PBMC DPD (μg mg−1 protein) | 0.488±0.052 | 0.124±0.072 | 0.848 | <0.01 | 0.612±0.109 | 0.364±0.102 | 1.681±0.141 | 18:48±0:41 | 6:40±0:38 |
| Human plasma UH2/Ura ratio | 5.074±0.642 | 2.751±0.398 | 0.633 | <0.001 | 7.825±0.981 | 2.323±0.314 | 3.368±0.498 | 18:33±0:52 | 6:45±0:41 |
| Human urine UH2/Ura ratio | 6.439±0.762 | 2.687±0.521 | 0.659 | <0.01 | 9.125±0.912 | 3.752±0.412 | 2.432±0.081 | 19:53±0:59 | 7:36±0:39 |
| Mesor | Amplitude | r2 | P | Maximum | Minimum | Maximum/minimum | Tmax (HALO) | Tmin (HALO) | |
| (b) | |||||||||
| Rat liver DPD (μg mg−1 protein) | 3.418±0.213 | 1.533±0.125 | 0.916 | <0.001 | 4.950±0.352 | 1.885±0.142 | 2.626±0.186 | 6:18±0:20 | 18:20±0:23 |
| Rat PBMC DPD (μg mg−1 protein) | 0.531±0.041 | 0.115±0.021 | 0.853 | <0.001 | 0.645±0.042 | 0.416±0.032 | 1.550±0.210 | 6:36±0:33 | 18:40±0:28 |
| Rat plasma UH2/Ura ratio | 0.390±0.048 | 0.185±0.019 | 0.822 | <0.001 | 0.575±0.036 | 0.205±0.020 | 2.805±0.400 | 5:08±0:24 | 17:15±0:32 |
| Rat urine UH2/Ura ratio | 0.294±0.019 | 0.131±0.021 | 0.568 | <0.01 | 0.425±0.031 | 0.163±0.011 | 2.607±0.216 | 4:23±0:28 | 16:37±0:43 |
Mesor: the rhythm-adjusted mean. Amplitude: maximum or minimum value from the mean.