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Chemical structures, efficacies and potencies of mTRPM8 antagonists and agonists
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Linalool, geraniol, hydroxycitronellal, WS-3, WS-23, FrescolatMGA, FrescolatML, PMD38, CoolactP and Cooling Agent 10 were identified as novel partial TRPM8 agonists. The efficacies and potencies of mTRPM8 antagonists and agonists are given. Changes in [Ca2+]i were measured using the FLIPR® described in Methods (n=4–8).
