Cardiovascular changes in the same conscious, male, Sprague – Dawley rats (n=8) given i.v. bolus injection of CsA (5.9 mg kg−1) in the presence of saline, losartan and SB 209670, or losartan, SB209670 and phentolamine. Values are mean and vertical bars show s.e.m.; P⩽0.05 versus baseline (Friedman's test). Between-experiment differences are given in the text.