Table 2.
Resting cardiovascular variables in the same group of animals (n=8) in the presence of saline, losartan+SB 209670, and losartan+SB209670+ phentolamine
| Saline | Losartan+SB209760 | Losartan+SB209760+phentolamine | |
|---|---|---|---|
| Heart rate (beats min−1) | 340±11 | 409±15* | 494±7* |
| Mean BP (mmHg) | 103±2 | 82±5* | 48±3* |
| Renal DS (kHz) | 7.9±0.7 | 8.3±0.8 | 6.2±0.6 |
| Mesenteric DS (kHz) | 8.4±0.9 | 10.3±0.9* | 8.4±0.9 |
| Hindquarters DS (kHz) | 4.3±0.4 | 4.4±0.4 | 7.6±0.4* |
| Renal VC ((kHz mmHg −1) 103) | 77±7 | 105±14* | 130±9* |
| Mesenteric VC ((kHz mmHg−1) 103) | 82±9 | 130±16* | 175±19* |
| Hindquarters VC ((kHz mmHg−1) 103) | 42±4 | 55±6* | 159±8* |
All values are mean±s.e.m. for recordings made before administration of CsA. DS=Doppler shift, VC=vascular conductance
*
P⩽0.05 versus saline treatment (Friedman's test).