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Pharmacokinetics of M826. Rats received an i.str. infusion of M826 (1.5 nmol) 10 min after malonate infusion and the compound's concentrations were determined by LC-MS. (a) M826 concentrations in the ipsilateral striatum 5, 30 min, 1, 6 or 24 h after M826 infusion (n=3 rats per time point). Results are expressed as mean±s.e.m. (b) Log-linear regression of the i.str. concentration–time curve for the determination of the i.str. T1/2 of M826.
