Table 2.
Mean pharmacokinetic parameters for 6[S] 5-MTHF and 6[R] 5-MTHF after administration of either folk acid or 5-MTHF
| Folic acid | 6[S] 5-MTHF 5-MTHF | P-valuea | Folic acid | 6[R] 5-MTHF 5-MTHF | P-value | |
|---|---|---|---|---|---|---|
| Ke | 0.15 (0.1)b | 0.42 (0.2) | <0.001 | 0.14 (0.04) | 0.13 (0.04) | 0.66 |
| T1/2 (h) | 4.9 (2.5) | 2.7 (2.6) | <0.01 | 5.2 (1.2) | 6.0 (2.6) | <0.05 |
| Tmax (h) | 2.3 (0.8) | 1.3 (0.5) | <0.001 | 2.4 (0.7) | 1.6 (0.5) | <0.001 |
| Cmax (ng ml−1) | 14 (11) | 129 (33) | <0.001 | 42 (10) | 145 (47) | <0.001 |
| AUC 0–12 | 73 (39) | 383 (113) | <0.001 | 523 (180) | 700 (223) | <0.05 |
| AUC 0–∞ | 96 (48) | 405 (117) | <0.001 | 701 (284) | 924 (378) | <0.05 |
a
ANOVA one-way analysis.
b
s.d. within parentheses.