Table 3.
Pharmacokinetic parameters for 6[S] 5-MTHF after administration of either folic acid or 5-MTHF in patients with (TT) and (CC) genotype
| Genotype | TT | Folic acid CC | P-valuea | TT | 5-MTHF CC | P-value |
|---|---|---|---|---|---|---|
| Ke | 0.15 (0.1)b | 0.17 (0.1) | 0.56 | 0.32 (0.1) | 0.35 (0.2) | 0.66 |
| T1/2 (h) | 5.0 (2.0) | 4.8 (2.9) | 0.83 | 2.36 (0.7) | 2.82 (3.5) | 0.69 |
| Tmax (h) | 2.4 (0.8) | 2.3 (0.8) | 0.66 | 1.3 (0.5) | 1.2 (0.5) | 0.88 |
| Cmax (ng ml−1) | 14 (11) | 14 (7) | 0.83 | 101 (29) | 107 (36) | 0.66 |
| AUC 0–12 | 72 (39) | 74 (41) | 0.90 | 303 (105) | 329 (121) | 0.58 |
| AUC 0–∞ | 99 (37) | 94 (55) | 0.82 | 312 (111) | 340 (123) | 0.35 |
a
ANOVA one-way analysis.
b
s.d. within parentheses.