Table 1.

Spontaneous blood pressure and heart rate variability at rest

		Mean arterial pressure
	n	Mean (mmHg)	Variance	CV (%)
Conscious mice
WT	23	111±3	11.0±1.0	2.9±0.1
α2A-KO	24	118±2*	20.3±3.0*	3.7±0.3*
Anaesthetized mice
WT	6	97±8	5.7±1.0	2.6±0.4
α2A-KO	10	84±2	28.5±8.9*	5.6±0.8*
		Heart rate
	n	Mean (beats min−1)	Variance	CV (%)
Conscious mice
WT	23	565±14	911.8±266.1	4.8±0.6
α2A-KO	24	596±9*	354.2±54.4*	3.0±0.2*
Anaesthetized mice
WT	6	510±37	700.4±202.2	5.0±0.8
α2A-KO	10	573±25	135.5±54.2*	1.8±0.3*

After a 35–50 min stabilization period, the mean arterial pressure and heart rate were measured every second during the next 10 min; the mean, variance, and coefficient of variation (CV) were calculated from the 600 values thus obtained. Values are means±s.e.m. of n experiments.

^*P<0.05 versus WT.