Table 1.

Pharmacology of cannabinoid compounds

Compound	CB1 receptor activity	CB2 receptor activity	References
Plant cannabinoids
THC	Partial agonist	Partial agonist	Gerard et al. (1991), Bayewitch et al. (1996)
Δ8-THC	Partial agonist	Partial agonist	Matsuda et al. (1990), Gerard et al. (1991)
Cannabinol	Partial agonist	Partial agonist	Rhee et al. (1997), Condie et al. (1996)
Cannabidiola	No activity	No activity	Showalter et al. (1996)
Endogenous cannabinoids
Anandamide	Partial agonist	Partial agonist	Bayewitch et al. (1995), Rinaldi-Carmona et al. (1996)
2-AG	Agonist	Agonist	Stella et al. (1997), Sugiura et al. (2000)
Synthetic cannabinoids
HU210	Agonist	Agonist	Slipetz et al. (1995), Song and Bonner (1996)
CP55940	Agonist	Agonist	Little et al. (1988)
WIN55212-2	Agonist	Agonist	Tao and Abood (1998)
JWH-015	No activity	Agonist	Showalter et al. (1996)
JWH-133	No activity	Agonist	Hanus et al. (1999)
ACEA	Agonist	No activity	Hillard et al. (1999)
Methanandamide	Agonist	Partial agonist	Lin et al. (1998), Berglund et al. (1998)
SR144528	No activity	Antagonist	Rinaldi-Carmona et al. (1998)
SR141716A	Antagonist	No activityb	Rinaldi-Carmona et al. (1994)
AM251	Antagonist	No activity	Gatley et al. (1997), Simonean et al. (2001)

^aCannabidiol acts as an antagonist on a presently uncloned cannabinoid receptor (Jarai et al., 1999).

^bSR141716A binds to CB2 receptors at concentrations in the high nanomolar range and above (reviewed in Howlett et al., 2002).P<0.05 versus WT.)