Table 2.
Inflammatory properties of selected cytokines
| Cytokine | Neuroinflammatory property | References |
|---|---|---|
| IFN-γ | Proinflammatory | Benveniste (1998), Popko et al. (1997) |
| IL-1β | Proinflammatory | Loddick et al. (1998), Rothwell and Luheshi (2000) |
| IL-4 | Anti-inflammatory | Chao et al. (1993), Kitamura et al. (2000) |
| IL-6 | Pro- or anti-inflammatorya | Campbell (1998), Raivich et al. (1999) |
| IL-8 | Proinflammatory | Cuzner and Opdenakker (1999) |
| IL-12 | Proinflammatory | Segal et al. (1998), Constantinescu et al. (1998) |
| MCP-1 | Proinflammatory | Mahad and Ransohoff (2003) |
| TGFβ | Anti-inflammatory | Wyss-Coray et al. (2001), Bright and Sriram (2001) |
| TNFα | Proinflammatory | Bezzi et al. (2001), Lenzlinger et al. (2001) |
a
IL-6 can have pro- or anti-inflammatory outcomes likely determined by the simultaneous presence of other cytokines.