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. 2004 Feb 2;141(5):860–866. doi: 10.1038/sj.bjp.0705669

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Copyright 2004, Nature Publishing Group

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Vasodilator effects of Ang 1–7 in vessels treated with losartan (30 μM) and precontracted with NE before and after treatment with A 779. Effects of Ang IV and CGP 42112 A in vessels treated with losartan (30 μM) and precontracted with NE. Ordinate: vasodilation (%), expressed as a percentage decrease of the vasoconstriction induced by NE. Abscissa: log dose of Ang 1–7; Ang IV and CGP 42112 A. Each point is presented as mean±s.e.m. n=7–8 rats/group (panel (a)). Vasodilator effects of Ang II and Ang IV obtained before (control responses), just after, and 1, 3 and 5 min after injections of Divalinal-Ang IV in vessels treated with losartan (30 μM). Ordinate: vasodilation (%), expressed as a percentage decrease of the vasoconstriction induced by NE. Abscissa: doses of Ang IV and Ang II. Each bar is presented as mean±s.e.m. n=5–8 rats (panel (b)). ^*Significantly different from the corresponding control response (P<0.05).