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. 2004 Mar 1;141(6):1015–1023. doi: 10.1038/sj.bjp.0705693

Figure 3.

Figure 3

Kinetic profile of 3H-MADAM binding to murine cerebral cortex in vivo. The radioligand (4 μCi in 0.2 ml 0.9% NaCl) was injected i.v. in the tail after 5–120 min (x-axis, n=3). Subsequently, the radioactivity in 0.5 ml cerebral cortex homogenate was measured (y-axis) and is expressed on the graph as counts per minute (c.p.m.). The specific binding reached a maximum after 15 min. Citalopram (30 mg kg−1) defined the nonspecific binding and was given s.c. 30 min before administration of 3H-MADAM.