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Concentration-dependent effects of Ang II (1–100 nM) (n=8–10) on aortic cyclic GMP content relative to control (n=15) (a), and the effect of pretreatment with either (b) losartan (0.1 μM) (n=7) or (c) PD 123319 (1 μM) (n=5). *P<0.05, **P<0.01, ***P<0.001 versus respective group control (one-way ANOVA).
