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. 2004 Feb 23;141(6):1048–1058. doi: 10.1038/sj.bjp.0705701

Figure 2.

Figure 2

Efficacy and antagonism sensitivity of ATP- and α,β-meATP-induced currents of DRG neurons. (a) Plots of response amplitude (as % of maximum) versus log agonist concentrations. Responses to ATP or α,β-meATP were very similar, indicating analogous efficacy and potency. Data were normalized with respect to the response evoked by 100 μM ATP. Data are from 5 to 8 cells. (b) Plot of response amplitude against log concentrations of the antagonist TNP-ATP. Open squares indicate 10 μM ATP responses while filled squares are for 10 μM α,β-meATP responses. Note similar antagonism. Data are from five paired cells.