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. 2004 Feb 23;141(6):1048–1058. doi: 10.1038/sj.bjp.0705701

Figure 7.

Figure 7

Conditioning with low dose of α,β-meATP can induce strong potentiation of ATP current of DRG neuron. (a) After a control response to 10 μM ATP (first trace on the left), subsequent response (2 min later) has smaller amplitude. Conditioning (1.5 min) with 100 nM α,β-meATP evokes no membrane current but it strongly depresses subsequent response to ATP (open star) applied immediately after terminating the application of α,β-meATP. The next ATP response (double star) is, however, largely enhanced. This enhancement is transient because the subsequent ATP application induces an ATP current amplitude like the one observed for the second response in the series. All ATP applications are spaced at 2 min interval. (b) Histograms showing average facilitation of 10 μM ATP test response by 100 nM α,β-meATP (n=5) and intensification of current depression by 100 nM ATP (n=6). The reproducible response amplitude is 100% (dashed line) before conditioning with either α,β-meATP or ATP. Asterisks indicate P<0.05.