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Comparison of onset of P2X3 receptor desensitization and recovery between DRG neurons and ROS cells
| Agonist | DRG cells | ROS/rP2X3 | ||||
|---|---|---|---|---|---|---|
| τ1 | τ2 | 1.5 min recovery | τ1 | τ2 | 1.5 min recovery | |
| ATP (10 μM) | 61±8 ms (n=14) | 421±88 ms (n=14) | 30±3% (n=12) | 88±24 ms (n=9) | 893±232 ms (n=9) | 29±6% (n=6) |
| αβ-meATP (10 μM) | 67±7 ms (n=14) | 450±95 ms (n=14) | 48±4% (n=10) | 94±36 ms (n=12) | 874±182 ms (n=12) | 74±5% (n=6) |
τ1 and τ2 correspond to the biexponential decline of membrane currents indicative of desensitization onset.
