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. 2004 Mar 1;141(6):1068–1076. doi: 10.1038/sj.bjp.0705703

Figure 2.

Figure 2

Concentration–relaxation curves for methacholine in endothelium-intact pulmonary artery rings (a) from DSR normotensive rats in normal Krebs solution (NK) plus twice-distilled water (TDW; closed circles; pD2=6.33±0.06a; nH=1.22±0.15a; %Emax=75±6a), in normal Krebs solution containing L-NAME (10 μM; open circles; pD2=6.79±0.16; nH=0.6±0.04; %Emax=11±1; P<0.05a), or from DSS hypertensive rats in normal Krebs solution plus twice-distilled water (closed triangles; pD2=6.49±0.17b; nH=1.49±0.20b; %Emax=77±8b), in normal Krebs containing L-NAME (10 μM; open triangles; pD2=5.81±0.12; nH=0.53±0.02; %Emax=9±1; P<0.05b), and (b) from salt-resistant normotensive rats in chloride-free buffer (Cl.Free) plus twice-distilled water (closed circles), in chloride-free buffer containing L-NAME (10 μM; open circles; nH=0.56±0.09; %Emax=14±3; P<0.05b), or from salt-sensitive hypertensive rats in chloride-free buffer plus twice-distilled water (closed triangles), and in chloride-free buffer containing L-NAME (10 μM; open triangles; nH=0.43±0.09; %Emax=12±1; P<0.05b). Each point represents a mean of six experiments±s.e.m.