Table 1.
Maximal contraction (Emax) and sensitivity of BTSM strips for KCl, histamine and methacholine after 8-day pretreatment in the absence or presence of 10 μM methacholine
| Control | Methacholine (10 μM) pretreated | |||
|---|---|---|---|---|
| Sensitivity | Emax (%) | Sensitivity | Emax (%) | |
| KCl | 20.8±1.1 | 100 | 25.7±0.9* | 37±5** |
| Histamine | 5.9±0.1 | 100 | 5.7±0.1* | 46±3** |
| Methacholine | 7.3±0.1 | 100 | 6.5±0.1* | 48±6* |
Sensitivity to KCl expressed as EC50 (mM); sensitivity to histamine and methacholine expressed as pEC50 (−log M). Data represent means±s.e.mean from four (methacholine) to eight (KCl, histamine) experiments, each performed in duplicate.
P<0.05;
P<0.001 compared to control.