Table 1.

Evolution of the parameters of macroscopic damage in TNBS colitic rats

	Damage score			Extension of necrosis (cm)			Colonic weight/length ratio (mg cm−1)
	1 (week)		2 (week)	1 (week)		2 (week)	1 (week)		2 (week)
Control		0 (0–0)			0			69.1±3.5
TNBS	5 (5–6)		4 (3–4)	2.3±0.2		0.8±0.1	170.2±13.4+		92.3±3.9+
Diosmectite	5 (1.8–5)*		3 (2–4)	1.0±0.2*		0.7±0.2	119.0±9.9+*		94.8±6.0+
Sulphasalazine	4 (4–6)		4 (2–4)	1.5±0.3		0.7±0.2	154.0±9.6+		83.8±4.9+

Results are expressed as median (25–75% quartiles) and mean±s.e.m., respectively.

^*P<0.05 compared with TNBS group. Groups TNBS, diosmectite and sulphasalazine were significantly different from the control group at all time points (not shown).