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Synthetic HNF-1α peptides' thermodynamic stabilities
| Peptide | ΔGu (H2O) | Peptide | ΔGu (H2O) |
|---|---|---|---|
| Wild type (wt) | 12.0 ± 0.1 | L12H | 8.3 ± 0.2 |
| wt-KEK | 11.8 ± 0.1 | G20R-KEK | 7.2 ± 0.3 |
ΔGu values (kcal/mol) were extrapolated to zero denaturant concentration at a 1 M standard-state peptide concentration. “KEK” designates N-terminal extension (see Table 1).
